Hi Doug,
on which system? Maybe an autostart-routine is running with a service of HamSphere. After rebooting I would check it in the Task-Manager (if you're running Windows) before starting the program.
Normally there is no HamSphere process in use.
And after starting HS 4 wait a few seconds before you click on "Transmitter" and "Default", maybe this helps. .
73 and good DX from Jörg :-)
JO31ok
Bochum / Germany